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Recent News:
November 2019 -- FocalCool presented at the Life Sciences Summit in New York City. September 2019 -- NIH Awarded FocalCool a Phase II SBIR Grant to continue work towards commercialization. Our goal is to achieve FDA clearance in 2020. Grateful for this support! November 2018 -- FocalCool, a Rowan University startup, successfully completed an NIH Phase I SBIR achieving all milestones related to device design and animal testing in collaboration with UMASS. A Combination Endovascular Device: Therapeutic Hypothermia with Stentriever Devices In the News: Rowan University News: Cooling Blood = Saving Lives SJTP Videos: FocalCool Interview and Summary NJN News: FocalCool on NJN |
Related Publications:
Myocardial tissue salvage is correlated with ischemic border region temperature at reperfusion. Merrill TL, Mitchell JE, Merrill DR, Gorman III JH, Gorman RC, Gillespie MJ. Myocardial tissue salvage is correlated with ischemic border region temperature at reperfusion. Catheter Cardiovasc Interv. 2019;1–9. Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept Jildaz Caroff, Robert M King, Jennifer E Mitchell, Miklos Marosfoi Joseph R Licwinko, Heather L Gray-Edwards, Ajit S Puri, Thomas L Merrill, Matthew J Gounis. Journal of NeuroInterventional Surgery Published Online First: 30 July 2019. doi: 10.1136/neurintsurg-2019-015179 The Impact of Patient-Specific Vascular Structure on Localized Cooling in the Human Heart. Spangenberg N, Merrill T, Mitchell J, Attaluri A. ASME. Frontiers in Biomedical Devices, 2019 Design of Medical Devices Conference(): V001T01A001. doi:10.1115/DMD2019-3223. E-140 Focal cooling through a novel insulated catheter allows fast and safe therapeutic hypothermia in a canine ischemic stroke model King R, Mitchell J, Brooks O, et al. Journal of NeuroInterventional Surgery 2018;10:A117-A118. Surface and Endovascular Cooling: Methods, Models, and Measurements, Theory and Applications of Heat Transfer in Humans Merrill, T.L., and Mitchell, J.E, , Wiley, New York, NY, pg. 741-752, ISBN: 978-1-119-12730-7, Jul 2018. Heat transfer analysis of catheters used for localized tissue cooling to attenuate reperfusion injury Merrill TL; Mitchell, JE, Merrill DR Medical Engineering & Physics, Vol 38, Issue 8, pp.758-766 (August 2016) A hemolysis study of an intravascular blood cooling system for localized organ tissue cooling. Merrill TL; Mingin T; Merrill D; Botbyl J; Akers (Mitchell) JE Perfusion. 2013 Jan;28(1):6-13. Improved Ease of Use Designs for Rapid Heart Cooling Thomas L. Merrill, Denise R. Merrill, and Jennifer E. Akers (Mitchell) J. Med. Devices 6(3), 035001 (Jul 30, 2012) Design of a Cooling Guide Catheter for Rapid Heart Cooling Thomas L. Merrill, Denise R. Merrill, Todd J. Nilsen and Jennifer E. Akers (Mitchell) J. Med. Devices 4(3), 035001 (Aug 31, 2010) A Chill To The Heart: A system to deliver local hypothermia could one day improve the lives of heart-attack patients. Tom Merrill Focus on Bioengineering. Mechanical Engineering-CIME. 2009 ASME |
Conference Presentations:
Spangenberg N, Mitchell J, Attaluri A, Merrill T., The impact of patient specific vascular structure on localized cooling in the human heart. In: Design of Medical Devices Conference. Minneapolis, MN: ASME; 2019:DMD2019-3223. http://www.dmd.umn.edu/2019/AdvancesCardio.html.
Sikorski, R., Merrill, D.R., and Merrill, T.L., Computational Modeling of the Canine Middle Cerebral Artery During Localized Hypothermia Stroke Treatment, SBC2013-14596, American Society of Mechanical Engineering (ASME) 2013 Summer Biomedical Engineering Conference, Sunriver, OR, June 20-23, 2013.
Sikorski, R., Merrill, D.R., and Merrill, T.L., Predicting Regional Brain Cooling Following Intracranial Thrombectomy, ASME Design of Medical Devices Conference, Minneapolis, MN, April, 2013.
Sikorski, R., Chapman, B.E., and Merrill, T.L., Two dimensional blood shear modeling in a blood cooling catheter, Comsol 2012 Conference Proceedings, Boston, MA, October 2012.
Sikorski, R., and Merrill, T.L., Three dimensional blood cooling model inside a carotid bifurcation, Comsol 2012 Conference Proceedings, Boston, MA, October 2012.
Mingin, T., Akers, J., Merrill, D.R., Chapman, B.E., Jones, B., Merrill, T.L., Ex Vivo Blood Damage Measurement for an Intravascular Blood Cooling and Delivery System, SBC2012-80546, American Society of Mechanical Engineering (ASME) 2012 Summer Biomedical Engineering Conference, Fajardo, Puerto Rico, June 20-23, 2012.
Merrill, T.L., Akers, J., Merrill, D.R., Localized Brain Tissue Cooling For Use During Intracranial Thrombectomy, SBC2012-80833, American Society of Mechanical Engineering (ASME) 2012 Summer Biomedical Engineering Conference, Fajardo, Puerto Rico, June 20-23, 2012.
Akers, J.E., Merrill, D.R., Gorman, R. L, Merrill, T.L. Localized Cooling Device for Myocardial Tissue Salvage, SBC2011-53155, American Society of Mechanical Engineering (ASME) 2011 Summer Biomedical Engineering Conference, Farmington, PA, June 22-25, 2011.
LaBarck, A, J., Akers, J.E., Merrill, T. L., Tissue Oxygen Transport during Reperfusion and Post-conditioning, SBC2011-53064 , American Society of Mechanical Engineering (ASME) 2011 Summer Biomedical Engineering Conference, Farmington, PA, June 22-25, 2011.
Constans, E., Kadlowec, J., Bhatia, K.K., Zhang, H., Merrill, H., and Angelone, B. Integrating the Mechanical Engineering Curriculum Using a Long-term Green Design Project Part 1: The Hybrid Powertrain, American Society of Engineering Educators (ASEE) 2012 ASEE Annual Conference and Exposition, San Antonio, TX, June 10-13, 2011.
La Barck, A.J., Akers. J.E., and Merrill, T.L., Fluid Dynamics of Blood Flow during Reperfusion and Post-conditioning, Comsol 2010 Conference Proceedings, Boston, MA, October 2010.
La Barck, A., Akers. J.E., and Merrill, T., Fluid Dynamics of Blood Flow during Reperfusion and Post-conditioning, Comsol 2009 Conference Proceedings, Boston, MA, October 2009.
Montgomery, P., Pavelchak, M., and Merrill, T,Structural Mechanics of Cooling Catheters, Comsol 2008 Conference Proceedings, Boston, MA, October 2008.
Fluid Dynamics of Blood Flow during Reperfusion and Post-conditioning, La Barck, A., Docimo, J, and Merrill, T., Comsol 2008 Conference Proceedings, Boston, MA, October 2008
Book Chapters:
Therapeutic Hypothermia, Edited by S. Mayer and D. Sessler, Chapter 9: Thermodynamics and Heat Transfer and co-author of Chapter 10: Surface and Endovascular Cooling. Marcel Dekker, New York, NY, (2005).
Spangenberg N, Mitchell J, Attaluri A, Merrill T., The impact of patient specific vascular structure on localized cooling in the human heart. In: Design of Medical Devices Conference. Minneapolis, MN: ASME; 2019:DMD2019-3223. http://www.dmd.umn.edu/2019/AdvancesCardio.html.
Sikorski, R., Merrill, D.R., and Merrill, T.L., Computational Modeling of the Canine Middle Cerebral Artery During Localized Hypothermia Stroke Treatment, SBC2013-14596, American Society of Mechanical Engineering (ASME) 2013 Summer Biomedical Engineering Conference, Sunriver, OR, June 20-23, 2013.
Sikorski, R., Merrill, D.R., and Merrill, T.L., Predicting Regional Brain Cooling Following Intracranial Thrombectomy, ASME Design of Medical Devices Conference, Minneapolis, MN, April, 2013.
Sikorski, R., Chapman, B.E., and Merrill, T.L., Two dimensional blood shear modeling in a blood cooling catheter, Comsol 2012 Conference Proceedings, Boston, MA, October 2012.
Sikorski, R., and Merrill, T.L., Three dimensional blood cooling model inside a carotid bifurcation, Comsol 2012 Conference Proceedings, Boston, MA, October 2012.
Mingin, T., Akers, J., Merrill, D.R., Chapman, B.E., Jones, B., Merrill, T.L., Ex Vivo Blood Damage Measurement for an Intravascular Blood Cooling and Delivery System, SBC2012-80546, American Society of Mechanical Engineering (ASME) 2012 Summer Biomedical Engineering Conference, Fajardo, Puerto Rico, June 20-23, 2012.
Merrill, T.L., Akers, J., Merrill, D.R., Localized Brain Tissue Cooling For Use During Intracranial Thrombectomy, SBC2012-80833, American Society of Mechanical Engineering (ASME) 2012 Summer Biomedical Engineering Conference, Fajardo, Puerto Rico, June 20-23, 2012.
Akers, J.E., Merrill, D.R., Gorman, R. L, Merrill, T.L. Localized Cooling Device for Myocardial Tissue Salvage, SBC2011-53155, American Society of Mechanical Engineering (ASME) 2011 Summer Biomedical Engineering Conference, Farmington, PA, June 22-25, 2011.
LaBarck, A, J., Akers, J.E., Merrill, T. L., Tissue Oxygen Transport during Reperfusion and Post-conditioning, SBC2011-53064 , American Society of Mechanical Engineering (ASME) 2011 Summer Biomedical Engineering Conference, Farmington, PA, June 22-25, 2011.
Constans, E., Kadlowec, J., Bhatia, K.K., Zhang, H., Merrill, H., and Angelone, B. Integrating the Mechanical Engineering Curriculum Using a Long-term Green Design Project Part 1: The Hybrid Powertrain, American Society of Engineering Educators (ASEE) 2012 ASEE Annual Conference and Exposition, San Antonio, TX, June 10-13, 2011.
La Barck, A.J., Akers. J.E., and Merrill, T.L., Fluid Dynamics of Blood Flow during Reperfusion and Post-conditioning, Comsol 2010 Conference Proceedings, Boston, MA, October 2010.
La Barck, A., Akers. J.E., and Merrill, T., Fluid Dynamics of Blood Flow during Reperfusion and Post-conditioning, Comsol 2009 Conference Proceedings, Boston, MA, October 2009.
Montgomery, P., Pavelchak, M., and Merrill, T,Structural Mechanics of Cooling Catheters, Comsol 2008 Conference Proceedings, Boston, MA, October 2008.
Fluid Dynamics of Blood Flow during Reperfusion and Post-conditioning, La Barck, A., Docimo, J, and Merrill, T., Comsol 2008 Conference Proceedings, Boston, MA, October 2008
Book Chapters:
Therapeutic Hypothermia, Edited by S. Mayer and D. Sessler, Chapter 9: Thermodynamics and Heat Transfer and co-author of Chapter 10: Surface and Endovascular Cooling. Marcel Dekker, New York, NY, (2005).